Bioactive Small Molecules
Cayman Chemical CL2SN38dIchLRoacetIc acI 5mg
A reactive drug-linker molecule containing SN-38 and a maleimidocaproyl linker; cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM) when linked to hMN-14 as an ADC; increases survival in a colon carcinoma mouse model of lung metastasis when linked to hMN-14
Selleck Chemical LLC Acetyl phosphate E5841-25MG
Acetyl phosphate(lithium potassium) is an endogenous metabolite bypasses the LytS membrane potential sensor by phosphorylating LytR twice as fast influencing lrgAB operon regulation in glucose-rich conditions without membrane potential disruption Lithium potassium acetyl phosphate is studied for its electrochemical properties and role in phosphorus chemistry with potential applications in lithium-ion battery technology and catalytic processes
Medchemexpress LLC HY-136453 5mg Medchemexpress, CR-1-31-B CAS:1352914-52-3 Purity:>98%
Medchemexpress, HY-136453 5mg CR-1-31-B CAS:1352914-52-3 CR-1-31-B is a potent eIF4A RNA helicase inhibitor. CR-1-31-B blocks MUC1-C translation in response to growth factor stimulation in breast cancer cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical JNJ-10229570 10mg
A melanocortin receptor antagonist (IC50s = 270, 240, and 200 nM for MC1R, MC4R, and MC5R, respectively, in radioligand binding assays); prevents bovine pituitary extract-induced increases in lipid droplets in primary human sebocytes at 0.05 µM; inhibits cholera toxin-induced increases in squalene and cholesterol esters, but not triglycerides, in primary human sebocytes at 1 µM; topical application inhibits sebum secretion from, and sebaceous gland differentiation in, transplanted human skin in a mouse xenograft model at 0.05%
Medchemexpress LLC HY-137537 50mg Medchemexpress, Pomalidomide-PEG2-azide CAS:2267306-14-7 Purity:>98%
Medchemexpress, HY-137537 50mg Pomalidomide-PEG2-azide CAS:2267306-14-7 Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical Alsma orIentals Alsol A 5mg
A terpenoid; inhibits HBV surface antigen secretion in HBV-infected 2.2.15 cells (IC50 = 39 µM); induces cell cycle arrest at the G0/G1 phase and autophagy in MDA-MB-231 human breast cancer cells at 20 and 40 µM; reduces hepatic steatosis and increases in plasma triglyceride, total cholesterol, LDL-C, and HDL-C levels in a mouse model of high-fat diet-induced obesity at 100 mg/kg per day; decreases blood glucose and insulin levels in intraperitoneal glucose and insulin tolerance tests, respectively, in the same model
STEMCELL Technologies Pluripotin, Size: 1 mg
Pluripotin inhibits both Ras GTPase-activating protein (RasGAP, Kd = 98 nM) and extracellular signal-regulated kinase 1 (ERK1, Kd = 212 nM; Chen et al.). Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK1 blocks differentiation (Chen et al.).MAINTENANCE AND SELF-RENEWAL· Promotes self-renewal and maintains mouse embryonic stem (ES) cells in an undifferentiated, pluripotent state in the absence of feeder cells, serum and leukemia inhibitory factor (LIF) for at least 10 passages (Chen et al.; Xiong et al.).· When combined with LIF, improves efficiency of ES cell derivation from refractory mouse strains (Pieters et al.; Yang et al.).
Cayman Chemical OLIGOMYCIN A 5MG
An inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM); exhibits antifungal, antitumor, and nematocidal activities, but has poor solubility in water and other biocompatible solvents
Medchemexpress LLC Chlorquinaldol | 72-80-0 | 98.7% | 1 G
Chlorquinaldol (Chloquinan) is an antibacterial agent that can be used for topical skin conditions and vaginal infections. It is also a β-catenin/TCF4 inhibitor, demonstrating anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells.
- Functions as an antibacterial agent
- Used for topical skin conditions and vaginal infections
- Acts as a β-catenin/TCF4 inhibitor
- Demonstrates anti-proliferation activity in cancer cells
- Shows anti-migration activity in cancer cells
- Induces apoptosis in cancer cells
Medchemexpress LLC L-hydroxyproline-d3 | 1356016-86-8 | 98.7% | 134.15 | C5H6D3NO3 | 10 MG
L-hydroxyproline-d3 is the deuterium-labeled form of L-hydroxyproline used as a stable-isotope reference standard and a chiral building block for synthesis and analytical workflows. It is provided in small, exact-quantity packages suitable for method development, isotopic tracing, and synthetic chemistry applications.
- stable isotope-labeled for accurate mass spectrometry quantitation
- high purity suitable for analytical use
- small package sizes minimize waste during method development
- suitable as a chiral building block in pharmaceutical synthesis
- delivered with lot-specific certificate of analysis for traceability
Medchemexpress LLC HY-101764 5mg Medchemexpress, Lintitript CAS:136381-85-6 Purity:>98%
Medchemexpress, HY-101764 5mg Lintitript CAS:136381-85-6 Lintitript (SR 27897) is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC50 of 6 nM and a Ki of 0.2 nM. Lintitript displays > 33-fold selectivity more selective for CCK1 than CCK2 receptors (EC50 value of 200 nM). Lintitript increases plasma concentration of leptin and food intake as well as plasma concentration of insulin[3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical MyclobutnIl-d9 5mg
An internal standard for the quantification of myclobutanil by GC- or LC-MS
Medchemexpress LLC HY-100716 5mg , Eganelisib CAS:1693758-51-8 Purity:>98%
HY-100716 5mg Eganelisib CAS: 1693758-51-8 Eganelisib (IPI549) is a potent and selective PI3Kγ inhibitor with an IC50 of 16 nM. Eganelisib shows >100-fold selectivity over other lipid and protein kinases. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-B0257A 5mg , Dydrogesterone CAS:152-62-5 Purity:>98%
HY-B0257A 5mg Dydrogesterone CAS: 152-62-5 Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC EMT inhibitor-2 | 2232228-60-1 | 98.8% | 1 ML
EMT inhibitor-2, also known as Compound 1, is an agent that inhibits epithelial-mesenchymal transition (EMT) induced by immunocyte-released substances like IL-1β and TGF-β. This compound also demonstrates inhibitory effects on CYP3A4 (testosterone) and CYP2C9.
- Inhibits epithelial-mesenchymal transition
- Inhibits CYP3A4 and CYP2C9 enzymes
- Molecular weight of 470.47
- Chemical formula: C24H26N2O8
- Appearance: Off-white to light yellow solid